A selective IDE inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM

ML-345 – 10 mg

Brand:
Cayman
CAS:
1632125-79-1
Storage:
-20
UN-No:
Non-Hazardous - /

Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling.{26503} In addition to regulating insulin action in diabetes pathogenesis, IDE plays a role in Varicella-Zoster virus infection and degradation of amyloid-β, a peptide implicated in Alzheimer’s disease. ML-345 is a small molecule inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM.{28670} It demonstrates 10-fold selectivity for IDE over a panel of enzymes with reactive cysteine residues.{28670}  

 

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Description

A selective IDE inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM

Formal name: 5-fluoro-2-[2-(4-morpholinyl)-5-(4-morpholinylsulfonyl)phenyl]-1,2-benzisothiazol-3(2H)-one

Synonyms: 

Molecular weight: 479.5

CAS: 1632125-79-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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