An inhibitor of the MITF pathway (IC50 = 1.2 μM for TRPM-1 promoter activity); selectively cytotoxic to the SK-MEL-5 and MALME-3M MITF-dependent melanoma cell lines over A375 MITF-independent cells (IC50s = 0.1

ML-329 – 5 mg

Brand:
Cayman
CAS:
19992-50-8
Storage:
-20
UN-No:
Non-Hazardous - /

ML-329 is an inhibitor of the microphthalmia-associated transcription factor (MITF) pathway with an IC50 value of 1.2 μM for promoter activity of the MITF target gene TRPM-1.{38954} It is selectively cytotoxic to the SK-MEL-5 and MALME-3M MITF-dependent melanoma cell lines over A375 MITF-independent cells (IC50s = 0.1, 0.7, and 70 μM, respectively).  

 

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Description

An inhibitor of the MITF pathway (IC50 = 1.2 μM for TRPM-1 promoter activity); selectively cytotoxic to the SK-MEL-5 and MALME-3M MITF-dependent melanoma cell lines over A375 MITF-independent cells (IC50s = 0.1, 0.7, and 70 μM, respectively),

Formal name: 4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-benzenesulfonamide

Synonyms: 

Molecular weight: 328.3

CAS: 19992-50-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death||Research Area|Cancer|Transcription Factors

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