A cell-permeable inhibitor of JMJD2E (KDM4DL; IC50 = 920 nM); reduces the expression of immediate early genes of HSV (IC50 = ~10 µM) and hCMV

ML-324 – 25 mg

Brand:
Cayman
CAS:
1222800-79-4
Storage:
-20
UN-No:
Non-Hazardous - /

ML-324 is a cell-permeable inhibitor of JMJD2E (KDM4DL; IC50 = 920 nM) that is inactive against lysine-specific demethylase, LSD1.{28754,28755} It reduces the expression of immediate early genes of Herpes simplex virus (IC50 = ~10 µM) and human cytomegalovirus, blocks viral infection, and suppresses the level of viral reactivation in a ganglia explant model of latently infected mice.{28754} The effects of ML-324 are reversible, as viral replication resumes after drug withdrawal.{28754}  

 

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Description

A cell-permeable inhibitor of JMJD2E (KDM4DL; IC50 = 920 nM); reduces the expression of immediate early genes of HSV (IC50 = ~10 µM) and hCMV, blocks viral infection, and suppresses the level of viral reactivation in a ganglia explant model of latently infected mice

Formal name: N-[3-(dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)-benzamide

Synonyms:  CID-44143209

Molecular weight: 349.4

CAS: 1222800-79-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Inhibitors|Demethylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HSV

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