A novel activator of the apoptotic arm of the UPR

ML-291 – 5 mg

Brand:
Cayman
CAS:
1523437-16-2
Storage:
-20
UN-No:
Non-Hazardous - /

ML-291 is a novel activator of the apoptotic arm of the unfolded protein response (UPR), but not the adaptive arm.{32821} Specifically, it activates signaling through PERK/eIF2α/CHOP (EC50 = 762 nM) but not through IRE1/XBP1 (IC50 > 80 µM).{32821} ML-291 induces apoptosis in mouse embryonic fibroblasts overexpressing CHOP (EC50 ~4.8 µM), but not in wild-type or CHOP knockout cells.{32821} It has minimal activity against a panel of 67 receptors, ion channels, and transporters, with the exception of the dopamine transporter (68% inhibition). ML-291 displays greater than average antitumor cell cytotoxicity against colon, melanoma, and renal cancer cell lines in an NCI-60 panel.{32821}  

 

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Description

A novel activator of the apoptotic arm of the UPR, but not the adaptive arm

Formal name: N-[4-[(4-chloro-1-piperidinyl)sulfonyl]phenyl]-5-nitro-2-furancarboxamide

Synonyms: 

Molecular weight: 413.8

CAS: 1523437-16-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Cell Death||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|ER Protein Folding

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