An inhibitor of cancer stem cells

ML-239 – 25 mg

Brand:
Cayman
CAS:
1378872-36-6
Storage:
-20
UN-No:
Non-Hazardous - /

ML-239 is an inhibitor of cancer stem cells, displaying greater than 23-fold selective inhibition of a breast cancer stem cell-like cell line (EC50 = 1.18 µM) over an isogenic control cell line (EC50 = 27.6 µM).{24522,24523,24524} It is also toxic to the breast carcinoma cell line MDA-MB-231.{24522} ML-239 alters the expression of genes in the MAPK, NF-κB, and inflammatory cytokine pathways.{24522,24524} It is stable in saline and modestly stable in human plasma.{24523}  

 

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Description

An inhibitor of cancer stem cells, displaying greater than 23-fold selective inhibition of a breast cancer stem cell-like cell line (EC50 = 1.18 µM) over an isogenic control cell line (EC50 = 27.6 µM); alters the expression of genes in the MAPK, NF-κB, and inflammatory cytokine pathways

Formal name: 2-(2,4,6-trichlorophenoxy)-acetic acid, (2E)-2-(1H-pyrrol-2-ylmethylene)hydrazide

Synonyms:  CID-49843203

Molecular weight: 346.6

CAS: 1378872-36-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cancer Stem Cell Research||Research Area|Cancer|Cell Death||Research Area|Cell Biology|Stem Cell Research

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