A GPX4 inhibitor; reduces viability of mesenchymal-state KP4 cells

ML-210 – 5 mg

Brand:
Cayman
CAS:
1360705-96-9
Storage:
-20
UN-No:
Non-Hazardous - /

ML-210 is an inhibitor of glutathione peroxidase 4 (GPX4).{43393} It reduces viability of mesenchymal-state KP4 cells, an effect that can be blocked by the arachidonic acid lipoxygenase inhibitors PD 146176 (Item No. 10010518) and zileuton (Item No. 10006967). It is also selectively lethal to mutant RAS oncogene-expressing cells (IC50s = 71 and 272 nM in HRASG12V-expressing and wild-type RAS-expressing BJeH cells, respectively).{33150}  

 

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SKU: 23282 - 5 mg Category:

Description

A GPX4 inhibitor; reduces viability of mesenchymal-state KP4 cells, an effect that can be blocked by arachidonic acid lipoxygenase inhibitors; selectively lethal to mutant RAS oncogene-expressing cells (IC50s = 71 and 272 nM in HRASG12V-expressing and wild-type RAS-expressing BJeH cells, respectively)

Formal name: [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)-methanone

Synonyms:  DPI10

Molecular weight: 475.3

CAS: 1360705-96-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death|Ferroptosis||Research Area|Cancer|Cell Signaling|GTPases||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Gluthathione Peroxidase

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