A potent synthetic agonist of GPR55 (EC50 = 0.26 µM); does not act at the related kynurenic acid receptor GPR35 and is a weak antagonist of CB1 and CB2 (IC50s = 21.8 and 15.1 µM

ML-184 – 1 mg

Brand:
Cayman
CAS:
794572-10-4
Storage:
-20
UN-No:
Non-Hazardous - /

GPR55 is a G protein-coupled receptor that is weakly activated by some cannabinoids (CBs) at nM concentrations but displays a 5- to 10-fold greater stimulation in response to 1 µM lysophosphatidylinositol (LPI).{17583,15021} ML-184 is a potent synthetic agonist of GPR55 (EC50 = 0.26 µM).{28660} It does not act at the related kynurenic acid receptor GPR35 and is a weak antagonist of CB1 and CB2 (IC50s = 21.8 and 15.1 µM, respectively).{28660} Like LPI, ML-184 induces phosphorylation of ERK1/2 and translocation of PKCβII to the plasma membrane by activating GPR55.{28660}  

 

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Description

A potent synthetic agonist of GPR55 (EC50 = 0.26 µM); does not act at the related kynurenic acid receptor GPR35 and is a weak antagonist of CB1 and CB2 (IC50s = 21.8 and 15.1 µM, respectively)

Formal name: 3-[[4-(2,3-dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)-benzenesulfonamide

Synonyms:  CID-2440433

Molecular weight: 470.6

CAS: 794572-10-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience

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