An inverse agonist of LRH-1 (IC50 = 3.7 µM) with maximum efficacy of 64% repression; inactive at the related SF1 transcriptional activator; alters the expression of haptoglobin

ML-180 – 10 mg

Brand:
Cayman
CAS:
863588-32-3
Storage:
-20
UN-No:
Non-Hazardous - /

ML-180 is an inverse agonist of liver receptor homolog-1 (LRH-1, IC50 = 3.7 µM) with maximum efficacy of 64% repression.{24526} It is inactive at the related steroidogenic factor-1 transcriptional activator.{24526} Through LRH-1, ML-180 alters the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the death of estrogen-receptor negative MDA-MB-231 breast cancer cells, and inhibits the steroidogenic acute regulatory promoter (IC50 = 2.05 µM).{24526}  

 

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Description

An inverse agonist of LRH-1 (IC50 = 3.7 µM) with maximum efficacy of 64% repression; inactive at the related SF1 transcriptional activator; alters the expression of haptoglobin, SAA1, and SAA4, induces the death of ER negative MDA-MB-231 breast cancer cells, and inhibits the StAR promoter (IC50 = 2.05 µM)

Formal name: 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-2,4(1H,3H)-pyrimidinedione

Synonyms:  CID-3238389|SR1848

Molecular weight: 388.9

CAS: 863588-32-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Research Area|Cancer|Transcription Factors||Research Area|Endocrinology & Metabolism|Hormones & Receptors

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