A potent inverse agonist of LRH-1 (IC50 = 320 nM) with maximum efficacy of 40% repression; inactive at the related SF1 transcriptional activator; alters the expression of haptoglobin

ML-179 – 1 mg

Brand:
Cayman
CAS:
1883548-87-5
Storage:
-20
UN-No:
Non-Hazardous - /

ML-179 is a potent inverse agonist of liver receptor homolog-1 (LRH-1) (IC50 = 320 nM) with maximum efficacy of 40% repression.{24526} It is inactive at the related steroidogenic factor-1 transcriptional activator.{24526} Through LRH-1, ML-180 alters the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the death of estrogen-receptor negative MDA-MB-231 breast cancer cells, and inhibits the steroidogenic acute regulatory promoter (IC50 = 2.12 µM).{24526}  

 

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Description

A potent inverse agonist of LRH-1 (IC50 = 320 nM) with maximum efficacy of 40% repression; inactive at the related SF1 transcriptional activator; alters the expression of haptoglobin, SAA1, and SAA4, induces the death of MDA-MB-231 breast cancer cells, and inhibits the StAR promoter (IC50 = 2.12 µM)

Formal name: 3-cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-2,4(1H,3H)-pyrimidinedione

Synonyms:  CID-45100448

Molecular weight: 422.4

CAS: 1883548-87-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Research Area|Cancer|Transcription Factors||Research Area|Endocrinology & Metabolism|Hormones & Receptors

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