A Kir2 channel inhibitor (IC50s = 1.8

ML-133 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
1222781-70-5
Storage:
-20
UN-No:
De Minimis - 3077 / 9

ML-133 is an inward-rectifier potassium channel 2 (Kir2) inhibitor (IC50s = 1.8, 2.8, 2,9, and 2.6 µM for Kir2.1, Kir2.2, Kir2.3, and Kir2.6, respectively).{61043} It is selective for Kir2 channels over Kir1.1 and Kir4.1 channels (IC50s = 33 and 76 µM, respectively). ML-133 (10 and 30 nmol/animal) prevents the development of dynamic, but not punctate, mechanical allodynia in a mouse model of spared nerve injury.{61040}  

 

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SKU: 31232 - 5 mg Category:

Description

A Kir2 channel inhibitor (IC50s = 1.8, 2.8, 2,9, and 2.6 µM for Kir2.1, Kir2.2, Kir2.3, and Kir2.6, respectively); selective for Kir2 channels over Kir1.1 and Kir4.1 channels (IC50s = 33 and 76 µM, respectively); prevents the development of dynamic, but not punctate, mechanical allodynia in a mouse model of spared nerve injury at 10 and 30 nmol/animal

Formal name: N-[(4-methoxyphenyl)methyl]-1-naphthalenemethanamine, monohydrochloride

Synonyms: 

Molecular weight: 313.8

CAS: 1222781-70-5

Purity: ≥98%

Formulation: A crystalline solid

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