A cationic rhodacyanine dye that inhibits the Hsp70 family of chaperones; demonstrates antiproliferative activity against cancer cell lines (EC50s = 1.4-2.2 µM in vitro) through its ability to abrogate the interaction of the chaperone with the tumor suppressor p53

MKT-077 – 5 mg

Brand:
Cayman
CAS:
147366-41-4
Storage:
-20
UN-No:
Non-Hazardous - /

MKT-077 is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s = 1.4-2.2 µM in vitro) through its ability to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones.{30109} It has been shown to bind to an allosteric site conserved in Hsp70 family members, interfering with ATP hydrolysis and abrogating the interaction of the chaperone with the tumor suppressor p53.{30110,30111}  

 

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Description

A cationic rhodacyanine dye that inhibits the Hsp70 family of chaperones; demonstrates antiproliferative activity against cancer cell lines (EC50s = 1.4-2.2 µM in vitro) through its ability to abrogate the interaction of the chaperone with the tumor suppressor p53

Formal name: 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium, monochloride

Synonyms:  FJ-776

Molecular weight: 432

CAS: 147366-41-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Heat Shock Proteins||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53||Research Area|Cell Biology|Cellular Chaperones

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