A potent FLAP antagonist that prevents 5-LO activation in vivo; inhibits LT biosynthesis in leukocytes with an IC50 value of 2.5 nM

MK-886 (sodium salt) – 5 mg

Brand:
Cayman
CAS:
118427-55-7
Storage:
-20
UN-No:
Non-Hazardous - /

Arachidonic acid (Item No. 90010) and selected other polyunsaturated fatty acids are stereoselectively oxygenated at carbon 5 by the non-heme iron containing enzyme 5-lipoxygenase (5-LO).{6777} The intervention of a second protein, 5-LO-activating protein (FLAP), is required before 5-LO can become catalytically active.{7937} MK-886 binds to FLAP with high-affinity and prevents 5-LO activation. MK-886 inhibits leukotriene biosynthesis in leukocytes with an IC50 of 2.5 nM.{2078} In human whole blood, leukotriene biosynthesis is inhibited by MK-886 with an IC50 of 1.1 µM.  

 

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SKU: 10133 - 5 mg Category:

Description

A potent FLAP antagonist that prevents 5-LO activation in vivo; inhibits LT biosynthesis in leukocytes with an IC50 value of 2.5 nM

Formal name: 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid, sodium salt

Synonyms: 

Molecular weight: 494.1

CAS: 118427-55-7

Purity: ≥99%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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