An Aurora A kinase inhibitor (IC50 = 0.6 nM); selective for Aurora A over Aurora B kinase (IC50 = 280 nM); induces cell cycle arrest at the G2/M phase in non-Hodgkin lymphoma cells at 1 μM; induces apoptosis and polyploidy in p53-positive and -negative HCT116 colon cancer cells

MK-8745 – 25 mg

Brand:
Cayman
CAS:
885325-71-3
Storage:
-20
UN-No:
Non-Hazardous - /

MK-8745 is an Aurora A kinase inhibitor (IC50 = 0.6 nM) that is selective for Aurora A over Aurora B kinase (IC50 = 280 nM).{49031} It induces cell cycle arrest at the G2/M phase in non-Hodgkin lymphoma cells when used at a concentration of 1 μM.{49032} MK-8745 (5 μM) induces apoptosis and polyploidy in p53-positive and -negative HCT116 colon cancer cells, respectively.{49031} It also induces apoptosis in sarcoma, melanoma, and pancreatic cancer cell lines in a p53-dependent manner when used at a concentration of 5 μM.  

 

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SKU: 26190 - 25 mg Category:

Description

An Aurora A kinase inhibitor (IC50 = 0.6 nM); selective for Aurora A over Aurora B kinase (IC50 = 280 nM); induces cell cycle arrest at the G2/M phase in non-Hodgkin lymphoma cells at 1 μM; induces apoptosis and polyploidy in p53-positive and -negative HCT116 colon cancer cells, respectively, at 5 μM; induces apoptosis in sarcoma, melanoma, and pancreatic cancer cell lines in a p53-dependent manner at 5 μM

Formal name: (3-chloro-2-fluorophenyl)[4-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-1-piperazinyl]-methanone

Synonyms: 

Molecular weight: 431.9

CAS: 885325-71-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Aurora||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|Aurora Signaling

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