A rapamycin analog that selectively inhibits mTOR (IC50 = 0.2 nM); binds FKBP12 to form a complex that associates with the FKBP-rapamycin binding domain on mTOR and allosterically inhibits mTORC1 kinase activity

MK-8669 – 5 mg

Brand:
Cayman
CAS:
572924-54-0
Storage:
-20
UN-No:
Non-Hazardous - /

MK-8669 is a rapamycin analog that selectively inhibits mTOR (IC50 = 0.2 nM). Like rapamycin, MK-8669 binds FKBP12 to form a complex that associates with the FKBP-rapamycin binding domain on mTOR and allosterically inhibits mTORC1 kinase activity.{27495} MK-8669 is more water soluble than rapamycin and is amenable to oral or intravenous administration. Formulations containing rapalogs, including MK-8669, have promise against a subset of cancers, including advanced kidney cancer.{27495} MK-8669 is also being examined for effectiveness against cancers when used in combination with other chemotherapeutic compounds.{33801,33802,33803}  

 

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SKU: 10543 - 5 mg Category:

Description

A rapamycin analog that selectively inhibits mTOR (IC50 = 0.2 nM); binds FKBP12 to form a complex that associates with the FKBP-rapamycin binding domain on mTOR and allosterically inhibits mTORC1 kinase activity

Formal name: 42-(dimethylphosphinate)rapamycin

Synonyms:  AP23573|Deforolimus|Ridaforolimus

Molecular weight: 990.2

CAS: 572924-54-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|mTOR||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling

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