An imidazole nucleoside with immunosuppressive properties; inhibits T cell proliferation in response to various mitogenic stimuli by 10-100% (1-50 µg/mL); inhibits proliferation of stimulated T cells (IC50 = 5 µg/ml); inhibits guanine nucleotide formation in T cells

Mizoribine – 100 mg

Brand:
Cayman
CAS:
50924-49-7
Storage:
-20
UN-No:
Non-Hazardous - /

Mizoribine is an imidazole nucleoside with immunosuppressive properties.{38729} It inhibits T cell proliferation in response to various mitogenic stimuli by 10-100% when used at concentrations ranging from 1 to 50 µg/mL. Mizoribine inhibits proliferation of stimulated T cells (IC50 = 5 µg/ml), which can be reversed by guanosine.{38730} It also inhibits guanine nucleotide formation in T cells, reducing GTP pools by 40-60% when used at a concentration of 5 µg/ml. Mizoribine inhibits replication of hepatitis C virus (HCV) RNA in vitro (IC50 = 100 µM).{38731} It suppresses glomerulosclerosis, urinary albumin excretion, interstitial fibrotic lesions, and macrophage infiltration into glomeruli and the interstitium in a rat model of type 2 diabetes when used at doses of 5 or 10 mg/kg.{38732} Mizoribine also reduces MCP-1, osteopontin (OPN), and TGF-β1 mRNA expression in the kidney in the same model. Formulations containing mizoribine have been used for the prevention of rejection after renal transplantation as well as in the treatment of lupus nephritis, rheumatoid arthritis, and primary nephritic syndrome.  

 

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SKU: 23128 - 100 mg Category:

Description

An imidazole nucleoside with immunosuppressive properties; inhibits T cell proliferation in response to various mitogenic stimuli by 10-100% (1-50 µg/mL); inhibits proliferation of stimulated T cells (IC50 = 5 µg/ml); inhibits guanine nucleotide formation in T cells, reducing GTP pools by 40-60% (5 µg/ml); inhibits replication of HCV RNA in vitro (IC50 = 100 µM); suppresses glomerulosclerosis, urinary albumin excretion, interstitial fibrotic lesions, and macrophage infiltration into glomeruli and the interstitium in a rat model of type 2 diabetes (5 or 10 mg/kg)

Formal name: 5-hydroxy-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide

Synonyms:  NSC 289637

Molecular weight: 259.2

CAS: 50924-49-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Nucleotides/Nucleosides||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Autoimmunity|Lupus||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Immunosuppressants||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Viral Diseases|Hepatitis

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