A DNA-binding

Mithramycin A – 5 mg

Brand:
Cayman
CAS:
18378-89-7
Storage:
-20
UN-No:
Non-Hazardous - /

Mithramycin A is a DNA-binding, anti-tumor and neuroprotective antibiotic originally isolated from S. grieseus that has long been used as a chemotherapeutic agent. It mediates its protective function, in part, by regulating acetylation of histones or transcription factors and, thereby, chromatin accessibility to transcriptional machinery. As a selective Sp1 inhibitor, mithramycin A binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, which inhibits their expression.{20905,20901} Mithramycin A (at 10-200 nM) can sensitize tumor cells to TRAIL-induced apoptosis and has been used to selectively target tumor cells in many different cancer models.{20904,20903,20902}  

 

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SKU: 11434 - 5 mg Category:

Description

A DNA-binding, anti-tumor and neuroprotective antibiotic that mediates its protective function, in part, by inhibiting Sp1 transcription factor binding to oncogene promoters; at 10-200 nM can sensitize tumor cells to TRAIL-induced apoptosis and has been used to selectively target tumor cells in many different cancer models

Formal name: (1S)-5-deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dideoxy-β-D-arabino-hexopyranosyl)-β-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-β-D-ribo-hexopyranosyl-(1→3)-O-2,6-dideoxy-β-D-lyxo-hexopyranosyl-(1→3)-2,6-dideoxy-β-D-arabino-hexopyranosyl)oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-1-O-methyl-D-threo-2-pentulose

Synonyms:  A 2371|Antibiotic LA 7017|Aureolic Acid|NSC 24559|PA 144|Plicamycin

Molecular weight: 1,085.20

CAS: 18378-89-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Transcription Factors

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