An internal standard for the quantification of misoprostol (free acid) by GC- or LC-MS.

Misoprostol (free acid)-d5 – 1 mg

Brand:
Cayman
CAS:
1337917-44-8
Storage:
-20
UN-No:
De Minimis - 1231 / 3

Misoprostol (free acid)-d5 contains five deuterium atoms at the 16 methyl, 17, and 17′ positions. It is intended for use as an internal standard for the quantification of misoprostol (free acid) by GC- or LC-mass spectrometry (MS). Misoprostol is a PGE1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors.{2313,1754,1752,1611} It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 µg/kg),{1754} inhibit superoxide generation in human neutrophils (EC50 = 0.35 µM),{1752} and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM){1611} in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with RU-486 for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.{2313}  

 

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SKU: 10010333 - 1 mg Category:

Description

An internal standard for the quantification of misoprostol (free acid) by GC- or LC-MS.

Formal name: 9-oxo-11α,16-dihydroxy-16-(methyl-d3)-prost-13E-en-1-oic-17,17-d2 acid

Synonyms: 

Molecular weight: 373.5

CAS: 1337917-44-8

Purity: ≥99% deuterated forms (d1-d5)

Formulation: A solution in methyl acetate

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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