A β3-adrenergic receptor agonist (EC50 = 22.4 nM) that displays potent selectivity for β3 compared to the β1 and β2 receptor subtypes (EC50s ≥ 10 µM); relaxes rat and human bladder strips precontracted with carbamoylcholine (EC50s = 5.1 and 0.78 µM

Mirabegron – 5 mg

Brand:
Cayman
CAS:
223673-61-8
Storage:
-20
UN-No:
Non-Hazardous - /

Mirabegron is a β3-adrenergic receptor agonist (EC50 = 22.4 nM) that displays potent selectivity for β3 compared to the β1 and β2 receptor subtypes (EC50s ≥ 10 µM).{28306} It has been shown to relax rat and human bladder strips precontracted with carbamoylcholine (Item No. 14486) with EC50 values of 5.1 and 0.78 µM, respectively.{28306} Clinical trials have supported the efficacy of mirabegron in overactive bladder therapy.{28307}  

 

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Description

A β3-adrenergic receptor agonist (EC50 = 22.4 nM) that displays potent selectivity for β3 compared to the β1 and β2 receptor subtypes (EC50s ≥ 10 µM); relaxes rat and human bladder strips precontracted with carbamoylcholine (EC50s = 5.1 and 0.78 µM, respectively)

Formal name: 2-amino-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-4-thiazoleacetamide

Synonyms:  YM-178

Molecular weight: 396.5

CAS: 223673-61-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area

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