A maleimide-derived small molecule that reactivates the tumor suppressor function of mutant p53

MIRA-1 – 50 mg

Brand:
Cayman
CAS:
72835-26-8
Storage:
-20
UN-No:
Non-Hazardous - /

MIRA-1 is a maleimide-derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human solid tumor cell lines carrying tetracycline-regulated mutant p53 (IC50 = 10 µM in vitro).{30490} Treatment of tumor cells with MIRA-1 induces p21, MDM2 and PUMA in a mutant p53-dependent manner.{30490} At a concentration of 5-10 mg/kg, MIRA-1, alone or in combination with dexamethasone (Item No. 11015), arrested tumor growth in a mouse xenograft model of multiple myeloma.{30491}  

 

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Description

A maleimide-derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human tumor cell lines carrying tetracycline-regulated mutant p53 (IC50 = 10 µM in vitro) and in vivo

Formal name: 1-[(1-oxopropoxy)methyl]-1H-pyrrole-2,5-dione

Synonyms:  NSC 19630

Molecular weight: 183.2

CAS: 72835-26-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53

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