An internal standard for the quantification of minoxidil by GC- or LC-MS

Minoxidil-d10 – 5 mg

Brand:
Cayman
CAS:
1020718-66-4
Storage:
-20
UN-No:
Non-Hazardous - /

Minoxidil-d10 contains 10 deuterium atoms on the piperidine ring. It is intended for use as an internal standard for the quantification of minoxidil (Item No. 15302) by GC- or LC-mass spectrometry. Minoxidil is a pyrimidine derivative that was originally developed as an anti-hypertensive agent and unexpectedly found to stimulate hair growth. Minoxidil directly affects arteriolar smooth muscle to decrease vascular resistance in part by opening ATP-sensitive potassium channels.{24983,24984} It can activate cyclooxygenase 1 (AC50 = 80 μM), which is expressed in the dermal papilla of hair follicles, increasing prostaglandin E2 production in BALB/c 3T3 fibroblasts and human dermal papilla fibroblasts.{4171}  

 

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Description

An internal standard for the quantification of minoxidil by GC- or LC-MS

Formal name: 6-(1-piperidinyl-d10)-2,4-pyrimidinediamine 3-oxide

Synonyms:  Loniten-d10|U-10858-d10

Molecular weight: 219.3

CAS: 1020718-66-4

Purity: ≥99% deuterated forms (d1-d10)

Formulation: A crystalline solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Research Area|Cardiovascular System|Vasculature|Smooth Muscle Cells||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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