A potent anti-hypertensive vasodilator that functions by opening ATP-sensitive potassium channels; activates COX-1 (AC50 = 80 μM) increasing PGE2 production in BALB/c 3T3 fibroblasts and human dermal papilla fibroblasts

Minoxidil – 500 mg

Brand:
Cayman
CAS:
38304-91-5
Storage:
-20
UN-No:
Non-Hazardous - /

Minoxidil is a pyrimidine derivative that was originally developed as an anti-hypertensive agent and unexpectedly found to stimulate hair growth. Minoxidil directly affects arteriolar smooth muscle to decrease vascular resistance in part by opening ATP-sensitive potassium channels.{24983,24984} It can activate cyclooxygenase 1 (AC50 = 80 μM), which is expressed in the dermal papilla of hair follicles, increasing prostaglandin E2 production in BALB/c 3T3 fibroblasts and human dermal papilla fibroblasts.{4171}  

 

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Description

A potent anti-hypertensive vasodilator that functions by opening ATP-sensitive potassium channels; activates COX-1 (AC50 = 80 μM) increasing PGE2 production in BALB/c 3T3 fibroblasts and human dermal papilla fibroblasts

Formal name: 6-(1-piperidinyl)-2,4-pyrimidinediamine 3-oxide

Synonyms:  Loniten|U-10858

Molecular weight: 209.3

CAS: 38304-91-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Small Molecule Activators||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension

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