A structural analog of γBB that inhibits γBB hydroxylase (IC50 = 62 µM) and carnitine acetyltransferase (Ki = 1.6 mM); has cardioprotective and neuroprotective effects; improves cognition and reduces amyloid-β pathology in a mouse model of Alzheimer’s disease

Mildronate (hydrate) – 100 mg

Brand:
Cayman
CAS:
86426-17-7
Storage:
-20
UN-No:
Non-Hazardous - /

Mildronate is a structural analog of γ-butyrobetaine (γBB), an intermediate in the biosynthesis of carnitine. It blocks carnitine synthesis by inhibiting γBB hydroxylase (IC50 = 62 µM) and, less potently, carnitine acetyltransferase (Ki = 1.6 mM).{26111,26108,26106} Through these actions, mildronate reduces the levels of free carnitine and long chain acyl carnitine.{26110,26109} This leads to suppressed fatty acid metabolism and mitochondrial uncoupling during oxidative conditions, resulting in cardioprotective and neuroprotective effects.{26110,26109,26107} Mildronate also improves cognition and reduces amyloid-β pathology in a mouse model of Alzheimer’s disease.{26112}  

 

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Description

A structural analog of γBB that inhibits γBB hydroxylase (IC50 = 62 µM) and carnitine acetyltransferase (Ki = 1.6 mM); has cardioprotective and neuroprotective effects; improves cognition and reduces amyloid-β pathology in a mouse model of Alzheimer’s disease

Formal name: 2-(2-carboxyethyl)-1,1,1-trimethyl-hydrazinium inner salt, dihydrate

Synonyms:  Meldonium|MET-88|Quaterine|THP

Molecular weight: 182.2

CAS: 86426-17-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Acetyltransferases||Research Area|Cardiovascular System||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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