An insecticidal and anthelmintic antibiotic; toxic to third instar gypsy moth larvae (LD50 = 0.119 µg/g); eradicates A. caninum and is effective against T. canis in dogs at 0.05 and 0.1 mg/kg; prevents D. immitis infection in dogs; activates glutamate- (EC50 = 89 nM) and GABA-gated chloride channels

Milbemycin D – 1 mg

Brand:
Cayman
CAS:
77855-81-3
Storage:
-20
UN-No:
Non-Hazardous - /

Milbemycin D is an insecticidal and anthelmintic antibiotic originally isolated from S. hygroscopicus.{37795} It is toxic to third instar gypsy moth larvae with an LD50 value of 0.119 µg/g but not to sixth instar larvae.{37796} Milbemycin D eradicates A. caninum and is effective against T. canis in dogs when administered at doses of 0.05 and 0.1 mg/kg.{37797} It prevents D. immitis infection in dogs, but is not effective against T. vulpis or D. caninum. Milbemycin D also activates glutamate- (EC50 = 89 nM) and GABA-gated chloride channels.{28250,37798}  

 

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Description

An insecticidal and anthelmintic antibiotic; toxic to third instar gypsy moth larvae (LD50 = 0.119 µg/g); eradicates A. caninum and is effective against T. canis in dogs at 0.05 and 0.1 mg/kg; prevents D. immitis infection in dogs; activates glutamate- (EC50 = 89 nM) and GABA-gated chloride channels

Formal name: 5-O-demethyl-28-deoxy-6R,28-epoxy-25R-(1-methylethyl)-milbemycin B

Synonyms:  Antibiotic B 41D

Molecular weight: 556.7

CAS: 77855-81-3

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases||Research Area|Neuroscience

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