A derivative of milbemycin A4 and a component of milbemycin oxime; reduces the number of microfilariae of the heartworm D. immitis in naturally infested dogs at 0.05 mg/kg; inhibits the growth of clinical isolates of C. glabrata (MIC80s = 16 to >32 μg/ml); blocks efflux of fluconazole from a clinical isolate of C. glabrata

Milbemycin A4 oxime – 5 mg

Brand:
Cayman
CAS:
93074-04-5
Storage:
-20
UN-No:
Non-Hazardous - /

Milbemycin A4 oxime is a derivative of milbemycin A4 (Item No. 17155) and a component of milbemycin oxime (Item No. 17164), compounds that both have insecticidal and nematocidal activity.{49156,49157} Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae of the heartworm D. immitis in naturally infested dogs.{49158} It inhibits the growth of clinical isolates of C. glabrata with MIC80 values ranging from 16 to greater than 32 μg/ml.{49156} Milbemycin A4 oxime (2.5 μg/ml) blocks efflux of fluconazole (Item No. 11594) from a clinical isolate of C. glabrata, but not from a strain lacking the efflux pumps CgCDR1 and PDH1, and reduces the MICs of fluconazole and 4-nitroquinoline 1-oxide in wild-type C. glabrata. It enhances adriamycin-induced inhibition of cell growth, as well as increases the intracellular accumulation of adriamycin and the P-glycoprotein substrate rhodamine 123 (Item No. 16672), in adriamycin-resistant, but not -sensitive, MCF-7 breast cancer cells in a concentration-dependent manner.{49159}  

 

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Description

A derivative of milbemycin A4 and a component of milbemycin oxime; reduces the number of microfilariae of the heartworm D. immitis in naturally infested dogs at 0.05 mg/kg; inhibits the growth of clinical isolates of C. glabrata (MIC80s = 16 to >32 μg/ml); blocks efflux of fluconazole from a clinical isolate of C. glabrata, but not from a strain lacking the efflux pumps CgCDR1 and PDH1, at 2.5 μg/ml; reduces the MICs of fluconazole and 4-nitroquinoline 1-oxide in wild-type C. glabrata; enhances adriamycin-induced inhibition of cell growth in adriamycin-resistant, but not -sensitive, MCF-7 breast cancer cells; increases the intracellular accumulation of adriamycin and rhodamine 123 in adriamycin-resistant, but not -sensitive, MCF-7 breast cancer cells

Formal name: (6R,25R)-5-demethoxy-28-deoxy-6,28-epoxy-25-ethyl-5-(hydroxyimino)-milbemycin B

Synonyms:  5-Ketomilbemycin A4 oxime|5-Oxomilbemycin A4 5-oxime

Molecular weight: 555.7

CAS: 93074-04-5

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Multidrug Resistance||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Infectious Disease|Parasitic Diseases

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