Description
A derivative of milbemycin A4 and a component of milbemycin oxime; reduces the number of microfilariae of the heartworm D. immitis in naturally infested dogs at 0.05 mg/kg; inhibits the growth of clinical isolates of C. glabrata (MIC80s = 16 to >32 μg/ml); blocks efflux of fluconazole from a clinical isolate of C. glabrata, but not from a strain lacking the efflux pumps CgCDR1 and PDH1, at 2.5 μg/ml; reduces the MICs of fluconazole and 4-nitroquinoline 1-oxide in wild-type C. glabrata; enhances adriamycin-induced inhibition of cell growth in adriamycin-resistant, but not -sensitive, MCF-7 breast cancer cells; increases the intracellular accumulation of adriamycin and rhodamine 123 in adriamycin-resistant, but not -sensitive, MCF-7 breast cancer cells
Formal name: (6R,25R)-5-demethoxy-28-deoxy-6,28-epoxy-25-ethyl-5-(hydroxyimino)-milbemycin B
Synonyms: 5-Ketomilbemycin A4 oxime|5-Oxomilbemycin A4 5-oxime
Molecular weight: 555.7
CAS: 93074-04-5
Purity: ≥99%
Formulation: A solid
Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Multidrug Resistance||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Infectious Disease|Parasitic Diseases
