A prodrug of the α1-adrenergic receptor agonist

Midodrine (hydrochloride) – 250 mg

Brand:
Cayman
CAS:
43218-56-0
Storage:
-20
UN-No:
Non-Hazardous - /

Midodrine is a prodrug of the α1-adrenergic receptor agonist, 1-(2’,5’-dimethoxyphenyl)-2-aminoethanol (Kis= 2, 6.9, and 1.7 µM for α1A, α1B, α1D, respectively).{29569} After oral administration it is completely absorbed via the intestinal H+-coupled peptide transporter 1 and converted to the active form through cleavage of a glycine residue.{29571} At 1-5 mg/kg, midodrine can produce a dose-related increase in mean arterial pressure in normotensive rats and improve the orthostatic index in an experimental model of postural hypotension.{29570}  

 

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Description

A prodrug of the α1-adrenergic receptor agonist, DMAE (Kis= 2, 6.9, and 1.7 µM for α1A, α1B, α1D, respectively); 1-5 mg/kg produces a dose-related increase in mean arterial pressure in normotensive rats and improves the orthostatic index in an experimental model of postural hypotension

Formal name: 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-acetamide, monohydrochloride

Synonyms: 

Molecular weight: 290.7

CAS: 43218-56-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypotension

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