Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria.{13247} They are responsible for periodic poisonings of humans and livestock drinking fresh water where the blue-green algae are endemic. Microcystin-LR is a selective inhibitor of PP2A (IC50= 0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM.{13248} The PP1 IC50 is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid

Microcystin-LR – 1 mg

Brand:
Cayman
CAS:
101043-37-2
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria.{13247} They are responsible for periodic poisonings of humans and livestock drinking fresh water where the blue-green algae are endemic. Microcystin-LR is a selective inhibitor of protein phosphatase 2A (PP2A) (IC50= 0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM.{13248} The PP1 IC50 is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose.  

 

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SKU: 10007188 - 1 mg Category:

Description

Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria.{13247} They are responsible for periodic poisonings of humans and livestock drinking fresh water where the blue-green algae are endemic. Microcystin-LR is a selective inhibitor of PP2A (IC50= 0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM.{13248} The PP1 IC50 is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose.

Formal name: cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl]

Synonyms:  Cyanoginosin-LR|Toxin T 17 (M. aeruginosa)

Molecular weight: 995.2

CAS: 101043-37-2

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Product Type|Biochemicals|Toxins|Microcystins||Research Area|Toxicology|Environmental|Aquatic Systems

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