Differs from the major microcystin variant LR with the substitution of alanine in place of the arginine; inhibits both PP1C and PP2A with an IC50 value of 0.3 nM

Microcystin-LA – 100 µg

Brand:
Cayman
CAS:
96180-79-9
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria.{13247} They are responsible for periodic poisonings of humans and livestock following consumption of freshwater in areas where the blue-green algae are endemic. The toxicity of microcystins is initiated by the inhibition of the catalytic activity of protein phosphatase (PP) 1 and PP2A.{14268} Microcystin-LA differs from the major microcystin variant LR (Item No. 10007188) with the substitution of alanine in place of the arginine. It inhibits both PP1C and PP2A with an IC50 value of 0.3 nM.{23564}  

 

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SKU: 10007187 - 100 µg Category:

Description

Differs from the major microcystin variant LR with the substitution of alanine in place of the arginine; inhibits both PP1C and PP2A with an IC50 value of 0.3 nM

Formal name: cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-alanyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl]

Synonyms:  Cyanoginosin-LA|Toxin BE4 (M. aeruginosa)

Molecular weight: 910.1

CAS: 96180-79-9

Purity: ≥95%

Formulation: A clear film

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Product Type|Biochemicals|Toxins|Microcystins||Research Area|Toxicology|Environmental|Aquatic Systems

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