A widely used antifungal imidazole that interferes with ergosterol synthesis in fungal cell membranes; induces reactive oxygen species in fungal biofilms

Miconazole (nitrate) – 10 g

Brand:
Cayman
CAS:
22832-87-7
Storage:
-20
UN-No:
Non-Hazardous - /

Miconazole is a widely used antifungal imidazole that acts by inhibiting the 14α-demethylation of lanosterol, which consequently leads to the inhibition of ergosterol synthesis in fungal cell membranes.{24644,23407} Additionally, miconazole has been shown to induce reactive oxygen species in fungal biofilms, demonstrating a MIC value of ≥256 μM against Candida spp.{25332}  

 

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Description

A widely used antifungal imidazole that interferes with ergosterol synthesis in fungal cell membranes; induces reactive oxygen species in fungal biofilms, demonstrating a MIC value of ≥256 μM against Candida spp

Formal name: 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole, mononitrate

Synonyms:  NSC 169434|R 14889

Molecular weight: 479.1

CAS: 22832-87-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals|Imidazoles||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|Demethylases||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases

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