An inhibitor of menin-MLL fusion protein interactions (IC50 = 648 nM); binds to menin (Kd = 201 nM) and inhibits the menin-MLL-AF9 interaction in HEK293 cells; inhibits growth of mouse BMCs expressing the Hoxa9 transformation-dependent MLL fusion proteins MLL-AF9 or MLL-ENL (IC50 = 5 µM for both); inhibits growth of human leukemia cell lines containing MLL translocations

MI-3 – 5 mg

Brand:
Cayman
CAS:
1271738-59-0
Storage:
-20
UN-No:
Non-Hazardous - /

MI-3 is an inhibitor of the interaction between menin and mixed lineage leukemia (MLL) fusion proteins (IC50 = 648 nM).{20716} MI-3 binds to menin (Kd = 201 nM) and inhibits the menin interaction with the MLL fusion protein MLL-AF9 in HEK293 cells without affecting protein levels of menin or MLL-AF9. It inhibits growth of mouse bone marrow cells (BMCs) expressing the Hoxa9 transformation-dependent MLL fusion proteins MLL-AF9 or MLL-ENL (IC50 = 5 µM for both), as well as reduces colony formation and induces differentiation of MLL-AF9-transformed BMCs. MI-3 inhibits growth of human leukemia cell lines containing MLL translocations and decreases the expression of the transcription factors HOXA9, HOXA10, and MEIS1 in THP-1 cells.  

 

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SKU: 27214 - 5 mg Category:

Description

An inhibitor of menin-MLL fusion protein interactions (IC50 = 648 nM); binds to menin (Kd = 201 nM) and inhibits the menin-MLL-AF9 interaction in HEK293 cells; inhibits growth of mouse BMCs expressing the Hoxa9 transformation-dependent MLL fusion proteins MLL-AF9 or MLL-ENL (IC50 = 5 µM for both); inhibits growth of human leukemia cell lines containing MLL translocations

Formal name: 4-[4-(4,5-dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)-thieno[2,3-d]pyrimidine

Synonyms: 

Molecular weight: 375.6

CAS: 1271738-59-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Transcription Factors

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