An inhibitor of tyrosine hydroxylase; reduces norepinephrine and dopamine levels in rat brains when administered at a dose of 200 mg/kg; disrupts conditioned avoidance behavior in a dose-dependent manner; reduces dexamethasone- and cyclosporin-induced hypertension in rats

Metyrosine – 250 mg

Brand:
Cayman
CAS:
672-87-7
Storage:
-20
UN-No:
Non-Hazardous - /

Metyrosine is an inhibitor of tyrosine hydroxylase.{35206} In vivo, metyrosine (200 mg/kg) reduces norepinephrine and dopamine levels in rat brain and disrupts conditioned avoidance behavior in a dose-dependent manner. Metyrosine reduces dopamine transporter knockdown-induced hyperactivity and rearing behavior and increases exploratory behavior in a hole board assay in a mouse model of bipolar disorder mania.{35226} It reduces hypertension induced by dexamethasone (Item No. 11015) and cyclosporin in rats.{35214,35212} Metyrosine also inhibits norepinephrine production and increases plasma levels of leptin in fasted and fed mice.{35210}  

 

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SKU: 24001 - 250 mg Category:

Description

An inhibitor of tyrosine hydroxylase; reduces norepinephrine and dopamine levels in rat brains when administered at a dose of 200 mg/kg; disrupts conditioned avoidance behavior in a dose-dependent manner; reduces dexamethasone- and cyclosporin-induced hypertension in rats

Formal name: α-methyl-L-tyrosine

Synonyms:  L-α-MT|MK-781|α-Methyl-L-p-tyrosine

Molecular weight: 195.2

CAS: 672-87-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Amino Acid Turnover||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Behavioral Neuroscience|Bipolar Disorder

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