An isoflavone; increases Rho activity in NHEMs at 1 µM; inhibits LPS-induced NO production in BV-2 microglia (IC50 = 7.8 µM); reduces hydrogen peroxide-induced production of ROS

Methylophiopogonanone B – 25 mg

Brand:
Cayman
CAS:
74805-91-7
Storage:
-20
UN-No:
Non-Hazardous - /

Methylophiopogonanone B is an isoflavone that has been found in O. japonicus and has diverse biological activities.{55050,55053,55051,55052} It increases Rho activity in normal human epidermal melanocytes (NHEMs) when used at a concentration of 1 µM.{55050} Methylophiopogonanone B inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia with an IC50 value of 7.8 µM.{55053} It reduces hydrogen peroxide-induced production of reactive oxygen species (ROS), apoptosis, and decreases in superoxide dismutase (SOD) activity in human umbilical vein endothelial cells (HUVECs) when used at concentrations of 40 and 50 µM.{55051} It is cytotoxic to SMMC-7721 and HeLa cancer cells (IC50s = 34.6 and 6 µg/ml, respectively).{55052}  

 

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SKU: 30193 - 25 mg Category:

Description

An isoflavone; increases Rho activity in NHEMs at 1 µM; inhibits LPS-induced NO production in BV-2 microglia (IC50 = 7.8 µM); reduces hydrogen peroxide-induced production of ROS, apoptosis, and decreases in SOD activity in HUVECs at 40 and 50 µM; cytotoxic to SMMC-7721 and HeLa cancer cells (IC50s = 34.6 and 6 µg/ml, respectively)

Formal name: (3R)-2,3-dihydro-5,7-dihydroxy-3-[(4-methoxyphenyl)methyl]-6,8-dimethyl-4H-1-benzopyran-4-one

Synonyms: 

Molecular weight: 328.4

CAS: 74805-91-7

Purity: ≥95%

Formulation: A crystalline solid

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