A homoisoflavonoid with diverse biological activities; increases the uptake of rosuvastatin and atorvastatin in HEK293T cells expressing human OATP1B1 (EC50s = 11.33 and 6 µM

Methylophiopogonanone A – 5 mg

Brand:
Cayman
CAS:
74805-92-8
Storage:
-20
UN-No:
Non-Hazardous - /

Methylophiopogonanone A is a homoisoflavonoid that has been found in O. japonicus roots and has diverse biological activities.{49616,49617,49618,49619} It increases the uptake of rosuvastatin (Item Nos. 12029 | 18813) and atorvastatin (Item No. 10493) in HEK293T cells expressing human organic anion transporting polypeptide 1B1 (OATP1B1; EC50s = 11.33 and 6 µM, respectively).{49617} Methylophiopogonanone A scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS (Item No. 27317) radicals in cell-free assays.{49616} In vivo, methylophiopogonanone A (10 mg/kg) decreases body weight gain and reduces serum and hepatic lipid levels in a rat model of high-fat diet-induced hyperlipidemia.{49618} It also reduces infarct size and myocardial apoptosis in mouse model of ischemia-reperfusion injury induced by transient occlusion of the left anterior descending coronary artery.{49619}  

 

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SKU: 30192 - 5 mg Category:

Description

A homoisoflavonoid with diverse biological activities; increases the uptake of rosuvastatin and atorvastatin in HEK293T cells expressing human OATP1B1 (EC50s = 11.33 and 6 µM, respectively); scavenges DPPH and ABTS radicals in cell-free assays; decreases body weight gain and reduces serum and hepatic lipid levels in a rat model of high-fat diet-induced hyperlipidemia at 10 mg/kg; reduces infarct size and myocardial apoptosis in mouse model of ischemia-reperfusion injury induced by transient occlusion of the left anterior descending coronary artery

Formal name: (3R)-3-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-4H-1-benzopyran-4-one

Synonyms: 

Molecular weight: 342.3

CAS: 74805-92-8

Purity: ≥98%

Formulation: A crystalline solid

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