A cationic dye with diverse biological activities; inhibits the catalytic function of inducible and constitutive nitric oxide synthases; inhibits MAO and increases the activity of mitochondrial cytochrome C oxidase; stabilizes systemic circulation without increasing peripheral resistance

Methylene Blue (hydrate) – 25 g

Brand:
Cayman
CAS:
122965-43-9
Storage:
-20
UN-No:
Non-Hazardous - /

Methylene blue is a cationic thiazine dye that has diverse biological activities.{47160,47163,47161} It inhibits the catalytic function of inducible and constitutive nitric oxide synthases via oxidation of enzyme-bound ferrous iron.{47160} Methylene blue also inhibits monoamine oxidase (MAO) and increases the activity of mitochondrial cytochrome C oxidase (complex IV).{47163,47161} In vivo, methylene blue stabilizes systemic circulation without increasing peripheral resistance, decreases lipid peroxidation, and reduces anoxic tissue injury in brain and heart in a porcine model of global ischemia and reperfusion injury.{47160} It inhibits MAO activity in brain and reduces the age-related decline in grip strength and spatial memory in old mice when administered in drinking water at a concentration of 250 μM.{47163} Methylene blue (15, 30, and 60 mg/kg) also reduces immobility time in the forced swim test in mice, indicating antidepressant-like activity.{47161} Methylene blue is commonly used to stain cells and tissues in research.{47162}  

 

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SKU: 26095 - 25 g Category:

Description

A cationic dye with diverse biological activities; inhibits the catalytic function of inducible and constitutive nitric oxide synthases; inhibits MAO and increases the activity of mitochondrial cytochrome C oxidase; stabilizes systemic circulation without increasing peripheral resistance, decreases lipid peroxidation, and reduces anoxic tissue injury in brain and heart in a porcine model of global ischemia and reperfusion injury; inhibits MAO activity in brain and reduces the age-related decline in grip strength and spatial memory in old mice at 250 μM in drinking water; reduces immobility time in the forced swim test in mice at 15,30, and 60 mg/kg; commonly used to stain cells and tissues in research

Formal name: 3,7-bis(dimethylamino)-phenothiazin-5-ium, monochloride, hydrate

Synonyms:  NSC 617593|Tetramethylthionine

Molecular weight: 319.9

CAS: 122965-43-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Labeling & Detection|Dyes, Stains, & Indicators||Product Type|Biochemicals|Small Molecule Inhibitors|Nitric Oxide Synthases||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Neurodegenerative Disorders||Research Area|Neuroscience|Neuroprotection|Ischemia

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