A phenol with diverse biological activities; reduces adipogenic hormonal stimulation-induced lipid accumulation in 3T3-L1 cells at 50 µM; active against V. cholerae in vitro (MIC = 32 µg/ml) and reduces V. cholerae-induced intestinal fluid accumulation in suckling mice at 50

Methyl Gallate – 100 g

Brand:
Cayman
CAS:
99-24-1
Storage:
-20
UN-No:
Non-Hazardous - /

Methyl gallate is a phenol that has been found in Meliaceae and has diverse biological activities.{61066,61081,32922,31596} It reduces adipogenic hormonal stimulation-induced lipid accumulation in 3T3-L1 cells when used at a concentration of 50 µM.{61066} Methyl gallate is active against V. cholerae in vitro (MIC = 32 µg/ml) and reduces V. cholerae-induced intestinal fluid accumulation in suckling mice when administered at doses of 50, 100, and 200 mg/kg.{61081} It reduces tumor growth and decreases the number of intratumor CD25+Foxp3high regulatory T cells (Tregs) in an EL-4 model of murine lymphoma.{32922} Methyl gallate (0.7, 7, and 70 mg/kg) reduces knee joint edema and leukocyte, neutrophil, and mononuclear cell infiltration in a mouse model of zymosan-induced arthritis.{31596}  

 

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Description

A phenol with diverse biological activities; reduces adipogenic hormonal stimulation-induced lipid accumulation in 3T3-L1 cells at 50 µM; active against V. cholerae in vitro (MIC = 32 µg/ml) and reduces V. cholerae-induced intestinal fluid accumulation in suckling mice at 50, 100, and 200 mg/kg; reduces tumor growth and decreases the number of intratumor CD25+Foxp3high Tregs in an EL-4 model of murine lymphoma; reduces knee joint edema and leukocyte, neutrophil, and mononuclear cell infiltration in a mouse model of zymosan-induced arthritis at 0.7, 7, and 70 mg/kg

Formal name: 3,4,5-trihydroxy-benzoic acid, methyl ester

Synonyms:  Gallic Acid methyl ester|NSC 363001

Molecular weight: 184.1

CAS: 99-24-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Polyphenols||Research Area|Cancer|Immunology||Research Area|Endocrinology & Metabolism||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases|Cholera

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