A fluorogenic CYP1A1/2 substrate; O-demethylated by CYP1A1/2

Methoxyresorufin – 5 mg

Brand:
Cayman
CAS:
5725-89-3
Storage:
-20
UN-No:
Non-Hazardous - /

Methoxyresorufin is a fluorogenic substrate for the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2.{53819,53820,41695} Methyoxyresorufin is O-demethylated by CYP1A1/2, releasing resorufin, which displays excitation/emission maxima of 570/580 nm, respectively.{53819,53820,41695,50356} The appearance of resorufin fluorescence can be used to quantify CYP1A1/2 activity.  

 

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Description

A fluorogenic CYP1A1/2 substrate; O-demethylated by CYP1A1/2, releasing resorufin, which displays ex/em = 570/580 and can be used to quantify CYP1A1/2 activity

Formal name: 7-methoxy-3H-phenoxazin-3-one

Synonyms:  Resorufin methyl ether

Molecular weight: 227.2

CAS: 5725-89-3

Purity: ≥90%

Formulation: A solid

Application|Enzyme Activity||Application|Fluorescence||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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