A fluorescent probe for Aβ; used to detect and quantify plaques

Methoxy-X04 – 10 mg

Brand:
Cayman
CAS:
863918-78-9
Storage:
-20
UN-No:
Non-Hazardous - /

Methoxy-X04 is a brain-permeable fluorescent probe for amyloid-β (Aβ) to detect and quantify plaques, tangles, and cerebrovascular amyloid.{38022} It displays high in vitro binding affinity (Ki = 26.8 nM) for fibrillar β-sheet deposits and is used to image Aβ plaques in the brains of living APP/PS1 mice, a transgenic model of familial Alzheimer’s disease.{38022,38023} For in vivo imaging, APP/PS1 mice were injected with methoxy-X04 at a dose of 10 mg/kg, i.p., 24 hours prior to two-photon imaging.{38023} Methoxy-X04 displays an excitation peak at 750 nm with emission between 460 and 500 nm.{38023}  

 

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Description

A fluorescent probe for Aβ; used to detect and quantify plaques, tangles, and cerebrovascular amyloid; high in vitro binding affinity (Ki = 26.8 nM) for fibrillar β-sheet deposits; used for in vivo imaging in APP/PS1 mice; displays an excitation peak at 750 nm with emission between 460 and 500 nm,

Formal name: 4,4′-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bis-phenol

Synonyms: 

Molecular weight: 344.4

CAS: 863918-78-9

Purity: ≥95%

Formulation: A crystalline solid

Application|Fluorescence||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area

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