An inhibitor of thyroid hormone synthesis; a substrate of thyroid peroxidase; traps oxidized iodide and prevents its use by thyroglobulin; inhibits absorption of radiolabeled iodide by the thyroid gland in rats by 80.9% when used at a dose of 0.4 mg/kg

Methimazole – 100 mg

Brand:
Cayman
CAS:
60-56-0
Storage:
4
UN-No:
Non-Hazardous - /

Methimazole is an inhibitor of thyroid hormone synthesis.{37227},{37226} It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.{37225} It also reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type I diabetic BB/W rat.{37224} Formulations containing methimazole have been used in the treatment of hyperthyroidism.  

 

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Description

An inhibitor of thyroid hormone synthesis; a substrate of thyroid peroxidase; traps oxidized iodide and prevents its use by thyroglobulin; inhibits absorption of radiolabeled iodide by the thyroid gland in rats by 80.9% when used at a dose of 0.4 mg/kg

Formal name: 1,3-dihydro-1-methyl-2H-imidazole-2-thione

Synonyms:  NSC 38608

Molecular weight: 114.2

CAS: 60-56-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Thyroid Hormones

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