A carbonic anhydrase inhibitor (IC50 = 130 nM); reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma; reduces electroshock-induced seizures in rats (ED50 = 19.2 mg/kg); inhibits production of ROS in a PCN cellular model of SAH; reduces cerebral edema in a mouse model of SAH; larvicidal against A. aegypti (LC50 = 724 ppm)

Methazolamide – 250 mg

Brand:
Cayman
CAS:
554-57-4
Storage:
-20
UN-No:
Non-Hazardous - /

Methazolamide is a carbonic anhydrase inhibitor (IC50 = 130 nM).{36164} It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED50 value of 19.2 mg/kg.{36165} It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and reduces cerebral edema in a mouse model of SAH.{36166} Methazolamide is larvicidal, with a larvicidal concentration (LC50) value of 724 ppm, but has no activity when administered orally to adult A. aegypti.{36167} Formulations containing methazolamide have been used for the treatment of glaucoma.{36164}  

 

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SKU: 23413 - 250 mg Category:

Description

A carbonic anhydrase inhibitor (IC50 = 130 nM); reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma; reduces electroshock-induced seizures in rats (ED50 = 19.2 mg/kg); inhibits production of ROS in a PCN cellular model of SAH; reduces cerebral edema in a mouse model of SAH; larvicidal against A. aegypti (LC50 = 724 ppm)

Formal name: N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]-acetamide

Synonyms: 

Molecular weight: 236.3

CAS: 554-57-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Carbonic Anhydrase||Research Area|Neuroscience|Ophthalmology||Research Area|Neuroscience|Seizure Disorders||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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