An internal standard for the quantification of metformin by GC- or LC-MS

Metformin-d6 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
1185166-01-1
Storage:
-20
UN-No:
Non-Hazardous - /

Metformin-d6 is intended for use as an internal standard for the quantification of metformin (Item No. 13118) by GC- or LC-MS. Metformin is a biguanide with diverse biological activities.{21403,13720,43272,43273} Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice.{13720} It reduces weight gain, hepatic lipid droplet content, and total cholesterol, LDL cholesterol, and triglyceride levels in the plasma of diet-induced obese mice when administered at doses of 10 or 50 mg/kg per day.{43273} It also reverses increased hepatic triglyceride and apolipoprotein A5 levels, as well as hepatic steatosis, in a dose-dependent manner in an ob/ob mouse model of non-alcoholic fatty liver disease (NAFLD).{43274} Metformin (250 mg/kg) reduces tumor growth in an HCT116 p53– human colon cancer mouse xenograft model, but has no effect on HCT116 p53– tumors overexpressing recombinant S. cerevisiae Ndi1 NADH dehydrogenase, a single-subunit ortholog of the multi-subunit mammalian mitochondrial complex I.{43272} Formulations containing metformin have been used in the treatment of type 2 diabetes.  

 

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Description

An internal standard for the quantification of metformin by GC- or LC-MS

Formal name: N,N-dimethyl-d6-imidodicarbonimidic diamide, monohydrochloride

Synonyms:  1,1-Dimethylbiguanide hydrochloride-d6

Molecular weight: 171.6

CAS: 1185166-01-1

Purity: ≥98% deuterated forms (d1-d6)

Formulation: A crystalline solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Metabolism||Research Area|Cancer|Transcription Factors|p53||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Endocrinology & Metabolism|Nutrient Sensing

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