An active metabolite of thioridazine; formed via sulfoxidation of thioridazine by CYP2D6 in human liver microsomes; binds to histamine H1

Mesoridazine – 10 mg

Brand:
Cayman
CAS:
5588-33-0
Storage:
-20
UN-No:
Non-Hazardous - /

Mesoridazine is an active metabolite of the typical antipsychotic thioridazine (Item No. 14400).{56193,56195} It is formed via sulfoxidation of thioridazine by the cytochrome P450 (CYP) isoform CYP2D6 in human liver microsomes.{56194} It binds to histamine H1, dopamine D2, muscarinic acetylcholine, and α1- and α2-adrenergic receptors (Kds = 1.8, 19, 69, 2, and 1,600 nM, respectively).{56195} Mesoridazine (10, 30, and 45 mg/kg, i.p.) prevents mescaline-induced hyperactivity in mice.{56196}  

 

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SKU: 31370 - 10 mg Category:

Description

An active metabolite of thioridazine; formed via sulfoxidation of thioridazine by CYP2D6 in human liver microsomes; binds to histamine H1, dopamine D2, muscarinic acetylcholine, and α1- and α2-adrenergic receptors (Kds = 1.8, 19, 69, 2, and 1,600 nM, respectively); prevents mescaline-induced hyperactivity in mice at 10, 30, and 45 mg/kg

Formal name: 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylsulfinyl)-10H-phenothiazine

Synonyms:  NSC 186066

Molecular weight: 386.6

CAS: 5588-33-0

Purity: ≥95%

Formulation: A solid

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