A heavy metal chelator; reverses sodium arsenite-induced inhibition of PDH in mouse kidney homogenates (ED50 = 0.25 mM); decreases cisplatin-induced increases in serum levels of platinum and BUN

meso-2,3-Dimercaptosuccinic Acid – 1 g

Brand:
Cayman
CAS:
304-55-2
Storage:
-20
UN-No:
Non-Hazardous - /

meso-2,3-Dimercaptosuccinic acid is a heavy metal chelator.{45474} It reverses sodium arsenite-induced inhibition of pyruvate dehydrogenase (PDH) in mouse kidney homogenates (EC50 = 0.25 mM). meso-2,3-Dimercaptosuccinic acid decreases cisplatin-induced increases in serum levels of platinum and blood urea nitrogen (BUN), as well as apoptosis in renal tubules of mice when administered at a dose of 100 µM/kg.{45475} meso-2,3-Dimercaptosuccinic acid (90 mg/kg) decreases elevations in the activity of catalase and glucose-6-phosphate dehydrogenase (G6PDH) in RBCs from lead-exposed rats, and decreases the levels of lead in the cerebellum, hippocampus, liver, kidney, and blood in rats when administered at a dose of 100 mg/kg.{45476,45477} It decreases immobility time in the forced swim test in lead-exposed male, but not female, mice when administered at a dose of 50 mg/kg.{45478} Formulations containing meso-2,3-dimercaptosuccinic acid have been used in the treatment of heavy metal poisoning.  

 

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SKU: 28515 - 1 g Category:

Description

A heavy metal chelator; reverses sodium arsenite-induced inhibition of PDH in mouse kidney homogenates (ED50 = 0.25 mM); decreases cisplatin-induced increases in serum levels of platinum and BUN, as well as apoptosis in renal tubules of mice at 100 µM/kg; decreases elevations in the activity of catalase and G6PDH in RBCs from lead exposed rats at 90 mg/kg; decreases the levels of lead in the cerebellum, hippocampus, liver, kidney, and blood in rats at 100 mg/kg; decreases immobility time in the forced swim test in lead-exposed male, but not female, mice at 50 mg/kg

Formal name: (2R,3S)-rel-2,3-dimercapto-butanedioic acid

Synonyms:  DMSA|Succimer

Molecular weight: 182.2

CAS: 304-55-2

Purity: ≥95%

Formulation: A crystalline solid

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