A carbapenem antibiotic; active against clinical isolates of Gram-positive and Gram-negative bacteria in vitro

Meropenem (hydrate) – 50 mg

Brand:
Cayman
CAS:
119478-56-7
Storage:
-20
UN-No:
Non-Hazardous - /

Meropenem is a carbapenem antibiotic.{26435} It is active against clinical isolates of Gram-positive and Gram-negative bacteria in vitro, including S. pneumoniae, H. influenzae, N. gonorrhoeae, E. coli, P. aeruginosa, C. difficile, and methicillin-susceptible and -resistant S. aureus (MICs = ≤0.008-8 μg/ml). It is protective against S. aureus, S. pneumoniae, E. coli, S. marcescens, P. mirabilis, and P. aeruginosa infections in mice with 50% protective dose (PD50) values of 0.13, 0.01, 0.04, 0.07, 0.84, and 0.46 mg/kg, respectively.{53193} Formulations containing meropenem have been used in the treatment of a variety of bacterial infections.  

 

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Description

A carbapenem antibiotic; active against clinical isolates of Gram-positive and Gram-negative bacteria in vitro, including S. pneumoniae, H. influenzae, N. gonorrhoeae, E. coli, P. aeruginosa, C. difficile, and methicillin-susceptible and -resistant S. aureus (MICs = ≤0.008-8 μg/ml); protective against S. aureus, S. pneumoniae, E. coli, S. marcescens, P. mirabilis, and P. aeruginosa infections in mice (PD50s = 0.13, 0.01, 0.04, 0.07, 0.84, and 0.46 mg/kg, respectively)

Formal name: (4R,5S,6S)-3-[[(3S,5S)-5-[(dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, trihydrate

Synonyms:  ICI 194660|SM-7338

Molecular weight: 437.5

CAS: 119478-56-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Carbapenems||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|MRSA||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia||Research Area|Infectious Disease|Bacterial Diseases|STDs

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