A vitamin K2 analog; increases osteocalcin

Menaquinone 7 – 5 mg

Brand:
Cayman
CAS:
2124-57-4
Storage:
-20
UN-No:
Non-Hazardous - /

Menaquinone 7 (MK-7) is a vitamin K2 analog that has been found in a variety of fermented foods.{41834} It increases osteocalcin, osteoprotegerin, and RANKL mRNA expression in osteoblastic MC3T3E cells. MK-7 (1 µM) increases alkaline phosphatase activity and calcium content in femoral-metaphyseal tissues isolated from normal and skeletal-unloaded rats.{41835} In vivo, MK-7 (100 µg/g diet) inhibits aortic and myocardial calcification and decreases aortic alkaline phosphatase tissue concentrations in a rat model of extraosseous calcification.{41836} It also increases trabecular number, bone mineral density, and bone mineral content in a rat model of ovariectomy-induced bone loss.{41837}  

 

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SKU: 10011051 - 5 mg Category:

Description

A vitamin K2 analog; increases osteocalcin, osteoprotegerin, and RANKL mRNA expression in osteoblastic MC3T3E cells; increases alkaline phosphatase activity and calcium content in femoral-metaphyseal tissues isolated from normal and skeletal-unloaded rats at 1 µM; inhibits aortic and myocardial calcification and decreases aortic alkaline phosphatase tissue concentrations in a rat model of extraosseous calcification at 100 µg/g diet; increases trabecular number, bone mineral density, and bone mineral content in a rat model of ovariectomy-induced bone loss

Formal name: 2-(-3,7,11,15,19,23,27-heptamethyloctacosa-2E,6E,10E,14E,18E,22E,26-heptaen-1-yl)-3-methylnaphthalene-1,4-dione

Synonyms:  MK-7|Vitamin K2(35)|Vitamin MK-7

Molecular weight: 649

CAS: 2124-57-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Prenol Lipids||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins||Research Area|Lipid Biochemistry|Prenol Lipids

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