An internal standard for the quantification of menaquinone 4 by GC- or LC-MS

Menaquinone 4-d7 – 250 µg

Brand:
Cayman
CAS:
1233937-25-1
Storage:
-20
UN-No:
Non-Hazardous - /

Menaquinone 4-d7 (MK-4-d7) is intended for use as an internal standard for the quantification of MK-4 (Item No. 18423) by GC- or LC-MS. MK-4 is the predominant homolog of vitamin K2 and is composed of a naphthoquinone base with four isoprenoid units in the side chain.{29936} It is formed primarily via conversion of vitamin K1 (Item No. 21051) in vivo and accumulates in various tissues, including the brain.{37777,37778} MK-4 halts the cell cycle at the G1 phase in HepG2, Hep3B, and Huh7 hepatocellular carcinoma cells in a concentration-dependent manner.{37779} It also inhibits IκB kinase (IKK) activity, IκBα phosphorylation, and the transcriptional activity of NF-κB. Vitamin K2 may have a role in bone metabolism.{29936}  

 

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SKU: 25709 - 250 µg Category:

Description

An internal standard for the quantification of menaquinone 4 by GC- or LC-MS

Formal name: 2-(methyl-d3)-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]-1,4-naphthalenedione-5,6,7,8-d4

Synonyms:  MK-4-d7|Vitamin K2(20)-d7

Molecular weight: 451.7

CAS: 1233937-25-1

Purity: ≥99% deuterated forms (d1-d7)

Formulation: An oil

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Research Area|Cancer|Cell Cycle|G1||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins

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