A homolog of vitamin K2; formed primarily via conversion of vitamin K1 in vivo; halts the cell cycle at the G1 phase in HepG2

Menaquinone 4 – 100 mg

Brand:
Cayman
CAS:
863-61-6
Storage:
-20
UN-No:
Non-Hazardous - /

Menaquinone 4 (MK-4) is the predominant homolog of vitamin K2 and is composed of a naphthoquinone base with four isoprenoid units in the side chain.{29936} It is formed primarily via conversion of vitamin K1 (Item No. 21051) in vivo and accumulates in various tissues, including the brain.{37777,37778} MK-4 halts the cell cycle at the G phase in HepG2, Hep3B, and Huh7 hepatocellular carcinoma cells in a concentration-dependent manner.{37779} It also inhibits IκB kinase (IKK) activity, IκBα phosphorylation, and the transcriptional activity of NF-κB. Vitamin K2 may have a role in bone metabolism.{29936}  

 

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Description

A homolog of vitamin K2; formed primarily via conversion of vitamin K1 in vivo; halts the cell cycle at the G1 phase in HepG2, Hep3B, and Huh7 hepatocellular carcinoma cells in a concentration-dependent manner; inhibits IκB, IκBα phosphorylation, and the transcriptional activity of NF-κB

Formal name: 2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]-1,4-naphthalenedione

Synonyms:  MK-4|Vitamin K2(20)

Molecular weight: 444.7

CAS: 863-61-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|IKKs||Product Type|Biochemicals|Natural Products|Vitamins||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins

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