Description
An NK2 receptor antagonist (pA2 = 8.08 in endothelium-deprived isolated rabbit pulmonary artery); selective for NK2 receptors in isolated rabbit pulmonary artery over NK2 receptors in isolated hamster trachea (pA2 = 5.64) and NK1 receptors in isolated guinea pig ileum (pA2 = 5.66), tissues that highly express these respective receptors, as well as NK3 receptors in isolated guinea pig cerebral cortex membranes (Ki = >10 μM); inhibits [β-Ala8]-NKA(4-10)-induced increases in bladder motility in anesthetized rats, as well as [β-Ala8]-NKA(4-10)-induced increases in bronchoconstriction in anesthetized guinea pig, at 1 and 3 μmol/kg
Formal name: L-α-aspartyl-L-tyrosyl-D-tryptophyl-L-valyl-D-tryptophyl-D-tryptophyl-L-lysinamide
Synonyms: Asp-Tyr-Trp-Val-Trp-Trp-Lys-NH2|DYWVWWK-NH2
Molecular weight: 1,081.20
CAS: 135306-85-3
Purity: ≥98%
Formulation: A crystalline solid
