A selective inhibitor of COX-2 (IC50s = 11.8 and 143 μM for COX-2 and COX-1

Meloxicam – 100 mg

Brand:
Cayman
CAS:
71125-38-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Meloxicam is a selective inhibitor of COX-2 (IC50s = 11.8 and 143 μM for COX-2 and COX-1, respectively, in an enzyme activity assay) and a non-steroidal anti-inflammatory drug (NSAID).{5788} Meloxicam (0.03%) reduces croton oil-induced increases in TNF-α and IL-1β mRNA levels and increases IL-10 mRNA levels in cornea in a rabbit model of acute ocular inflammation.{15890} It inhibits pleural plasma exudation in a carrageenan-induced rat model of pleurisy when administered at a dose of 3 mg/kg.{5788} In a canine model of unilateral osteoarthritis of the right stifle joint, meloxicam reduces prostaglandin E2 (PGE2) levels in plasma and right stifle joint synovial fluid when administered at a dose of 0.2 mg/kg.{13042} Formulations containing meloxicam have been used in the treatment of osteoarthritis and rheumatoid arthritis.  

 

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Description

A selective inhibitor of COX-2 (IC50s = 11.8 and 143 μM for COX-2 and COX-1, respectively, in an enzyme activity assay) and an NSAID; reduces croton oil-induced increases in TNF-α and IL-1β mRNA levels and increases IL-10 mRNA levels in cornea in a rabbit model of acute ocular inflammation at 0.03%; inhibits pleural plasma exudation in a carrageenan-induced rat model of pleurisy at 3 mg/kg; reduces PGE2 levels in plasma and right stifle joint synovial fluid in a canine model of unilateral osteoarthritis of the right stifle joint at 0.2 mg/kg

Formal name: 4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-1,1-dioxide-2H-1,2-benzothiazine-3-carboxamide

Synonyms:  UH-AC 62XX

Molecular weight: 351.4

CAS: 71125-38-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Ophthalmology||Research Area|Neuroscience|Pain Research

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