An antibiotic derived from P. chrysogenum that inhibits S. aureus and E. coli FabI (IC50s = 40.1 and 33.2 µM

Meleagrin – 1 mg

Brand:
Cayman
CAS:
71751-77-4
Storage:
-20
UN-No:
Non-Hazardous - /

Meleagrin is an antibiotic derived from a deep ocean, penicillin-producing P. chrysogenum.{28881} It is produced as an end product in the roquefortine branched biosynthetic pathway.{28882,28883} Meleagrin has been identified as an inhibitor of the bacterial enoyl-acyl carrier protein reductase (FabI) with IC50 values of 40.1 and 33.2 µM for S. aureus and E. coli FabI, respectively.{28881} It inhibits the growth of S. aureus, E. coli, and S. pneumoniae with MICs ranging from 32-64 µg/ml.{28881}  

 

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Description

An antibiotic derived from P. chrysogenum that inhibits S. aureus and E. coli FabI (IC50s = 40.1 and 33.2 µM, respectively); inhibits the growth of S. aureus, E. coli, and S. pneumoniae with MICs ranging from 32-64 µg/ml,,

Formal name: (3E,7aR,12aS)-7a-(1,1-dimethyl-2-propen-1-yl)-7a,12-dihydro-6-hydroxy-3-(1H-imidazol-5-ylmethylene)-12-methoxy-1H,5H-imidazo[1′,2′:1,2]pyrido[2,3-b]indole-2,5(3H)-dione

Synonyms:  6-O-Methyloxaline

Molecular weight: 433.5

CAS: 71751-77-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia

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