Immunogen: Synthetic peptide from the N-terminal region of mouse protein MC4R • Host: Rabbit • Species Reactivity: (+) Human

Melanocortin-4 Receptor Polyclonal Antibody – 1 ea

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Cayman
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Melanocortins are known to exert a broad array of physiological actions including ‘melanogenesis, steroidogenesis, sexual function and inflammation, as well as appetite regulation and energy homeostasis’.{12351} These actions are mediated (differentially or concurrently) in part by a family of G protein-coupled receptors, the melanocortin receptors 1-5 (MC1R-MC5R). Melanocortin-4 receptor (MC4R) was first cloned in 1993 with transcripts expressed primarily in the brain.{13229} Genetic studies of mice and humans have established a critical role of MC4R in appetite regulation.{3777} Heterozygous mutations in MC4R account for 1-6% of severe cases of human obesity. Thus, MC4R has been a prime target for therapeutic intervention in obesity.{10617} All known mammalian MC4Rs are 332 amino acids in length with an estimated molecular weight of 37 kDa. The protein is heavily glycosylated and appears at multiple positions on SDS-PAGE.{13230} Cayman’s MC4R Polyclonal Antibody mainly detects an unglycosylated protein at 37 kDa and a glycosylated protein at 55 kDa.  

 

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SKU: 10006355 - 1 ea Category:

Description

Immunogen: Synthetic peptide from the N-terminal region of mouse protein MC4R • Host: Rabbit • Species Reactivity: (+) Human, mouse, and rat • Applications: IHC (formalin-fixed paraffin-embedded sections) and WB

Synonyms: MC4R

Immunogen: Synthetic peptide from the N-terminal region of mouse protein MC4R

Formulation: 500 µl of Peptide affinity-purified antibody

Isotype:

Applications: IHC (formalin-fixed paraffin-embedded sections) and WB

Origin: Animal/Rabbit

Stability: 365 days

Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity

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